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KMID : 0613820110210040515
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Journal of Life Science
2011 Volume.21 No. 4 p.515 ~ p.520
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Immunomodulating Effect of Edible Mushrooms in Mice
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Park Hyun-Ji
Heo Yong
Kim Jong-Bong
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Abstract
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This study was carried out to evaluate the immunomodulatory capacity of edible mushrooms, including Lepista nuda, Corprinis comatus, Letinus edodes, and Pleurotus eryngii, in mice. BALB/c mice were administered 1, 50, and 500 ㎎/㎏ body weight of various mushrooms five times a week over 4 weeks through gastric intubation. The control mice were administered distilled water. No significant changes in body weight were observed. IL-4 and IFNγ production was evaluated with splenic T lymphocytes stimulated in vitro with phytohemagglutinins for 48 hr. The mice group administered L. edodes showed significantly higher ratio of IFNγ versus IL-4 than the other groups. In addition, the ratio of plasma IgG2a versus IgG1 was also significantly elevated in mice treated with L. edodes. However, no significant change was observed in ratio of IgG2a versus IgG1 in splenic B lymphocytes stimulated in vitrowith lipopolysaccharides for 7 days. These results indicate that L. edodescan enhance type-1 helper T cell-mediated cellular immunity.
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KEYWORD
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Mushroom, immunomodulator, anticancer, INFγ, IL-4
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